Hypopituitarism happens when your pituitary gland is not active enough. The front lobe of the gland may only partly work. Or it may not work at all. As a result the gland does not make enough hormones. In adults, GH deficiency may cause a decrease in energy and physical activity, change in body composition (increased fat, decreased muscle mass), a tendency toward increased cardiovascular risk factors/diseases and decreased quality of life (including an increased sense of social isolation).
Hypopituitarism has many causes. Any condition that damages the pituitary gland or the area of the brain known as the hypothalamus (which regulates the pituitary gland's function) can cause the pituitary to decrease hormone production. A pituitary tumor is . Hypopituitarism is a condition in which the pituitary gland (a small gland at the base of the brain) does not produce one or more of its hormones or not enough of them. This condition may occur because of disease in the pituitary or hypothalamus (a part of the brain that contains hormones that control the pituitary gland).
Hypopituitarism was associated with an overall excess mortality (weighted SMR, ; 95% CI, –) in adults. Female hypopituitary adults showed higher SMR compared with males ( vs ). Onset of hypopituitarism at a younger age was associated with higher SMR.